The paper is aimed at the basin and petroleum system modeling in the conjunction zone of the Alexander and Srednevasyugan anticlines and Ust-Tym depression during the Mesozoic-Cenozoic time. The exploration area is located in the southeastern part of the West Siberian hydrocarbon province. The present research primarily identifies the oil-window-entry time, maturity, generation points, generation power, and remaining potential of the Togur and Bazhenov source rocks. The Togur oil-window-entry time is 139.5 Ma. The Bazhenov oil-window-entry time is 99 Ma. Liquid hydrocarbons are extensively generated by the source rocks at the present time, since the Togur and Bazhenov Formations are found to be in the oil window. The significant amount of generated hydrocarbons is lost in migration processes. The source rock generation power and remaining potential are 1.1 and 1.5 billion tons of hydrocarbons, respectively.