The most spectacular macroevolutionary trend presented by the genera of schwagerinoid fusulinids, during the Pennsylvanian - Permian, is an enormous increase in size, which culminated in the Middle Permian with Eopolydiexodina. However, this potential major biogeographic marker, during the Kubergandian-early Midian time interval, is as yet hampered by its poor taxonomic characterization. Hence, Eopolydiexodina is revised here using biometric and morphometric methods applied to large collections from Afghanistan and selected taxa in the literature. These multivariate analyses consist of classical linear test parameters, as well as new area parameters acquired by computer image analysis. The Afghan species are re-defined, and some other species, occasionally described as Cimmerian, are re-discussed.