Sulfide-bearing mill wastes of the Salair Ore Processing Plant situated in the Kemerovo region (Russia) were investigated in the time period 1999-2011. Multipurpose studies of the Talmovskie mining tailings allowed the determination of the composition of the wastes, the acid mine drainages, and the affected groundwater. Geophysical sounding techniques (frequency sounding and electrical tomography) were used to trace the geoelectric zoning of the wastes, expressed as a consistent change of the electrical resistivity specific electrical resistance (SER) from zone to zone. Layers with low resistivity indicate areas with pore spaces filled by highly mineralized solutions. These layers extend to depths of 4-5 m, indicating the penetration of toxicants into the groundwater horizon. The pollution of groundwater was confirmed by chemical analysis, according to which the concentrations of Zn, Pb, and Cd in water samples from the wells are two to three orders of magnitude higher than the maximum permissible concentration (MPC). The authors provide an attempt to identify the correlation and quantitative relationships between SER and the total amount of various metal species present in the wastes and water extracts. The proposed approach permitted to estimate the amount of accumulated tailings, in order to predict changes in the total concentrations of Mn, Al, Fe, Cu, Zn, Cd, and Pb in waste and water extracts to a depth of 30 m.