The creation of technologies of rational use of mineral resources comprising complex extraction of wastes with an account of environmental impact of mining enterprises is possible only in wide application of the latest achievements of chemistry in mining industry. First of all it concerns the use of flotation reagents for selective separation of minerals, coagulants, polyelectrolytes and polymer flocculants to control the stability of disperse system in hydraulic mining, hydraulic transport, thickening, filtration, creaning of effluents.